Breast Cancer

U.S. scientists have found that the net Sekito Cancer Payudara show changes In gene expressions before and after the development of the disease, similar to that found on the net epithelial win. "This Payudara microenvironment of Cancer in Kaji Level transcriptome, and in previous studies and Epigenetic Level genomic, support Pandang tumor microenvironment that co-conspirator important than passive observers tumorigenesis Islam," reports Dennis Sgroi (Massachusetts General Hospital, Charlestown) and Working Partners . "In the Molecular Changes Stroma offers a novel face of disease and intervention Prognose" Mereke Trust.

Take the team used laser microdissection and microarray analysis of gene expression that is suitable for the sample you want to check the health and health disadvantage epithelial and stromal nets 14 are taken from various stages of the Women's Cancer Payudara. In the analysis shows the many changes Stroma In gene expressions related to the Healthy Payudara Cancer Compared with the net, "to the same extent as seen in the epithelium severe" In Journal Reports Researcher for Breast Cancer Research.

Dry special, found that team-Stroma tumor-related gene upregulation has been associated with the Extracellular matrix, matrix metalloproteinases (MMPs), and cell cycle gene. In addition, both tumor epithelium and Stroma was reduced cytoplasmic ribosomal protein expressions, PATTERN that is connected to tumor development, however the increased expressions Mitochondrial ribosomal protein. "In considering the importance of mitochondria of cancer, we found that the novel Mitochondrial ribosome may be many potential targets ensuring more studies," comments for Researchers.

In the example of Pasi ulcer with a mixture of ductal cancer in situ (DCIS) ductal invasive ulcer and cancer (IDC), where it changed from pre-invasive to invasive growth, there is an increase from expressions MMPs 2, 11, and 14. For Researchers suggest that "Stroma-produced MMPs may PLAYERS key driver DCIS-IDC transition." Finally, the team reports that, as found in the epithelium, Stroma tumor gene expressions have histologic thong waves associated with the class, with class III shows the net manga series and enhance the immune Kuate Answerer Mitotic activity.

Sgroi DKK concluded: "This gene expressions datasets from Exercise Exercise tumor epithelium in situ and must be purchased on time and Stroma Berharga side Resource for Cancer research Payudara community. Cancer treatment for select Payudara Originally identified in accordance with the stage of disease. Have some face treatment including operation, radiotherapy, and cytotoxic chemotherapy Endokrina Terapi gland. However, the management of each Pasi will depend on many factors including menopausal status, hormone receptor status is PERLAKUA preferences. End of Life PERLAKUA selected, after discussion with Pasi, will depend on individual circumstances making it difficult for the Treatment of disease by systematically manage algorithm